Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - A 425619

A 425619

CAS No. 581809-67-8

A 425619( 1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA )

Catalog No. M22193 CAS No. 581809-67-8

A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 177 In Stock
5MG 267 In Stock
10MG 408 In Stock
25MG 672 In Stock
50MG 945 In Stock
100MG 1278 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    A 425619
  • Note
    Research use only, not for human use.
  • Brief Description
    A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
  • Description
    A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPV1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    581809-67-8
  • Formula Weight
    345.33
  • Molecular Formula
    C18H14F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:34.5 mg/mL (100 mM; Need ultrasonic)
  • SMILES
    FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chakrabarti S , Pattison L A , Singhal K , et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner[J]. Neuropharmacology, 2018, 143.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • TRPV4 agonist-1 free...

    TRPV4 agonist-1 free base?is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).

  • SKF-96365 hydrochlor...

    SKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.

  • TC-I2000

    TC-I2000 is an TRPM8 channel blocker. Inhibits?icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50?of 53 nM.

Sign In Join Free