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A 425619

CAS No. 581809-67-8

A 425619 ( 1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA )

Catalog No. M22193 CAS No. 581809-67-8

A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    A 425619
  • Note
    Research use only, not for human use.
  • Brief Description
    A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
  • Description
    A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
  • Synonyms
    1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPV1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    581809-67-8
  • Formula Weight
    345.33
  • Molecular Formula
    C18H14F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:34.5 mg/mL (100 mM; Need ultrasonic)
  • SMILES
    FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chakrabarti S , Pattison L A , Singhal K , et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner[J]. Neuropharmacology, 2018, 143.
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